Deep neural networks have been extensively adopted for a myriad of applications due to their ability to learn patterns from large amounts of data. The desire to preserve user privacy and reduce user-perceived latency has created the need to perform deep neural network inference tasks on low-power consumer edge devices. Since such tasks often tend to be computationally intensive, offloading this compute from mobile/embedded CPU to a purposedesigned "Neural Processing Engines" is a commonly adopted solution for accelerating deep learning computations. While these accelerators offer significant speed-ups for key machine learning kernels, overheads resulting from frequent host-accelerator communication often diminish the net application-level benefit of this heterogeneous system. Our solution for accelerating such workloads involves developing ISA extensions customized for machine learning kernels and designing a custom in-pipeline execution unit for these specialized instructions. We base our ISA extensions on RISC-V: an open ISA specification that lends itself to such specializations. In this paper, we present the software infrastructure for optimizing neural network execution on RISC-V with ISA extensions. Our ISA extensions are derived from the RISC-V Vector ISA proposal, and we develop optimized implementations of the critical kernels such as convolution and matrix multiplication using these instructions. These optimized functions are subsequently added to the TensorFlow Lite source code and cross-compiled for RISC-V. We find that only a small set of instruction extensions achieves coverage over a wide variety of deep neural networks designed for vision and speech-related tasks. On average, our software implementation using the extended instructions set reduces the executed instruction count by 8X in comparison to baseline implementation. In parallel, we are also working on the hardware design of the inpipeline machine learning accelerator. We plan to open-source our software modifications to TF Lite, as well as the micro-architecture design in due course.